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| 孕甾烯醇酮吡咯化合物的制备 | |
| 引用本文： | 刘焕梅,李立军,孙晓然,韩美慧. 孕甾烯醇酮吡咯化合物的制备[J]. 精细石油化工, 2013, 30(3): 32-34 |
| 作者姓名： | 刘焕梅 李立军 孙晓然 韩美慧 |
| 作者单位： | 1. 河北联合大学轻工学院,河北唐山,063000 2. 河北大学化学与环境科学学院,河北保定,071002 3. 河北联合大学化学工程学院,河北唐山,063000 4. 湘南学院临床医学系,湖南郴州,423000 |
| 摘 要： | 以孕甾烯醇酮和盐酸羟胺为原料,碳酸氢钠为催化剂,二甲亚砜(DMSO)为溶剂制得孕甾烯醇酮肟,然后在氢氧化钾存在下与乙炔进行成环反应,合成了孕甾烯醇酮吡咯化合物。考察了催化剂用量,反应温度,反应时间对产率的影响。最佳合成条件为:常压,成环反应时间为6h,温度为115℃,催化剂用量为每10mLDMSO加425mg NaHCO3。孕甾烯醇酮吡咯(Ⅰ),产率为41.9%;N-乙烯基孕甾烯醇酮吡咯(Ⅱ),产率为30.3%.产物的熔点,IR及1 H NMR均与文献值一致。 |
| 关 键 词： | 孕甾烯醇酮 吡咯化合物 甾体化合物 酮肟 |
SYNTHESIS OF PREGNENOLONE PYRROLE COMPOUNDS |
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| Liu Huanmei , Li Lijun , Sun Xiaoran , Han Meihui. SYNTHESIS OF PREGNENOLONE PYRROLE COMPOUNDS[J]. Speciality Petrochemicals, 2013, 30(3): 32-34 | |
| Authors: | Liu Huanmei Li Lijun Sun Xiaoran Han Meihui |
| Affiliation: | 1.Hebei United University College of Light Industry,Tangshan063000,Hebei,China;2.College of Chemistry and Environmental Science,Hebei University,Baoding71002,Hebei,China;3.Hebei United University College of Chemical Engineering,Tangshan063000,Hebei,China;4.Xiangnan University,Department of Clinical Medicine,Chenzhou423000,Hu’nan,China) |
| Abstract: | Sodium bicarbonate was used as catalyst to synthesize pregnenolone oxime from Pregnenolone and hydroxylamine hydrochloride with dimethyl sulfoxide as solvent.Potassium hydroxide was added next with acetylene for cyclization reaction to synthesize pregnenolone pyrrole compounds.The effects of catalyst dosage,reaction temperature and reaction time on the productive rate were investigated.The optimum conditions were acquired as that reacted 6hat 115℃for the cyclization reaction under normal pressure with catalyst dosage of NaHCO3/mg∶DMSO/mL=425∶10.The productive rate of pregnenolone pyrrole(Ⅰ)is 41.9% while the N-vinyl pregnenolone pyrrole(Ⅱ)is 30.3%.Melting point,IR and 1 H NMR results of the products can consist with those in the literature. |
| Keywords: | pregnenolone pyrrole compounds sterols ketoxime |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |