| 二氢吡啶酮的不对称催化合成进展 |
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| 引用本文： | 贺顺龙,李飞,陈运荣.二氢吡啶酮的不对称催化合成进展[J].石油化工高等学校学报,2021,34(2):1. |
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| 作者姓名： | 贺顺龙 李飞 陈运荣 |
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| 作者单位： | 1. 辽宁石油化工大学 石油化工学院，辽宁 抚顺 113001； 2. 上海科技大学 物质科学与技术学院，上海 201210 |
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| 基金项目： | 青年科学基金项目“光促进的自由基共轭加成-不对称质子化反应”（21901162）。 |
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| 摘 要： | 手性吡啶酮骨架广泛存在于天然产物和具有生理活性的小分子药物中，实现该类手性结构的高效不对称催化合成具有重要的意义。总结了近年来发展的通过不对称环催化反应合成二氢吡啶酮的研究进展，详细阐述了氮杂?D?A反应与3+3]不对称环加成反应的各类催化模式以及它们之间的异同点，分析了各类催化剂的催化原理以及在它们作用下的反应历程，着重介绍了各方法的优势所在，并对该领域的发展进行了展望。
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| 关 键 词： | 二氢吡啶酮 不对称催化 氮杂Diels?Alder反应 [3+3]环加成 |
| 收稿时间： | 2020-04-09 |
Progress in Asymmetric Catalytic Synthesis of Dihydropyridinones |
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| He Shunlong,Li Fei,Chen Yunrong.Progress in Asymmetric Catalytic Synthesis of Dihydropyridinones[J].Journal of Petrochemical Universities,2021,34(2):1. |
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| Authors: | He Shunlong Li Fei Chen Yunrong |
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| Affiliation: | 1. School of Petrochemical Engineering，Liaoning Petrochemical University，Fushun Liaoning 113001， China； 2. School of Physical Science and Technology，Shanghai Tech University，Shanghai 201210，China |
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| Abstract: | Chiral pyridinone scaffolds widely exist in natural products and biologically active small molecules. Therefore, asymmetric catalytic synthesis with higher efficiency of these chiral compounds is of great importance, which has got significant improvement in this field recently.We reviewed the recent progress of asymmetric synthesis of dihydropyridinones through asymmetric cycloaddition reactions, compared the common points and differences between Aza?Diels?Alder reactions and 3 + 3] cycloadditions. The detailed catalytic mechanisms and advantages of these reactions were discussed, and the tendency of future development was also prospected. |
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| Keywords: | Dihydropyridinones Asymmetric catalysis Aza?Diels?Alder reaction [3+3] Cycloaddition |
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