| Vinamidinium盐的合成新工艺及其在固相反应中的应用 |
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| 引用本文： | 汪霞,高洁婷,翁意意. Vinamidinium盐的合成新工艺及其在固相反应中的应用[J]. 浙江化工, 2012, 0(8): 14-17 |
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| 作者姓名： | 汪霞 高洁婷 翁意意 |
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| 作者单位： | 浙江工业大学药学院 |
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| 摘 要： | 改进了一条Vinamidinium盐的合成路线,该路线以取代苯乙酸类化合物为原料,与Vislmeier试剂(BTC/DMF)反应,收率达到70%~88%;同时,初步探索了Vinamidinium盐在固相反应中的应用,合成了新的吡啶并[1,2-a]嘧啶衍生物,收率为40%~68%。
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| 关 键 词： | 双-(三氯甲基)-碳酸酯 Vinamidinium盐 吡啶并[1,2-a]嘧啶衍生物 固相反应 |
Synthesis of Vinamidinium Salts and its Application in Solid-Phase Reaction |
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| WANG Xia,GAO Jie-ting,WENG Yi-yi. Synthesis of Vinamidinium Salts and its Application in Solid-Phase Reaction[J]. Zhejiang Chemical Industry, 2012, 0(8): 14-17 |
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| Authors: | WANG Xia GAO Jie-ting WENG Yi-yi |
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| Affiliation: | (College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou 310014,China) |
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| Abstract: | Substituted acetic acids react with BTC in DMF to yield the Vinamidinium salts in moderate to excellent recrystallized yield(70%~88%).Five novel pyridopyrimidines in yield of 40%~68% were prepared from Vinamidinium salts and 2-amino-4-(2-chloro-6-fluorophenyl)-6-phenylsulfanylpyridine-3,5-dicarbonitrile(4) by solid-phase method. |
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| Keywords: | bis-(trichloromethyl)-carbonate Vinamidinium salts pyridopyrimidine solid-phase reaction |
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