Molecular epidemiology of Staphylococcus aureus and Enterococcus faecalis in endophthalmitis |
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| Authors: | MC Booth KL Hatter D Miller J Davis R Kowalski DW Parke J Chodosh BD Jett MC Callegan R Penland MS Gilmore |
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| Affiliation: | Department of Ophthalmology and Dean A. McGee Eye Institute, Molecular Pathogenesis of Eye Infection Research Center, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA. mary-booth@uokhsc.edu |
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| Abstract: | Genomic DNA fingerprint analysis was performed on 39 Staphylococcus aureus and 28 Enterococcus faecalis endophthalmitis isolates collected from multiple clinical centers. Among 21 S. aureus genomic DNA fingerprint patterns identified, five clonotypes were recovered from multiple unrelated patients and accounted for 58.9% (23 of 39) of the isolates analyzed. Compared with strains having unique genomic DNA fingerprint patterns, the S. aureus clonotypes occurring more than once were more likely to result in visual acuities of 20/200 or worse (P = 0.036 chi2 test]). In contrast to the S. aureus isolates, the E. faecalis endophthalmitis isolates were a clonally diverse population, enriched for the expression of a known toxin, cytolysin, which is plasmid encoded. |
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