Characterization of poly(vinylferrocenium) coated surfaces and their applications in DNA sensor technology |
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| Authors: | Filiz Kuralay Arzum Erdem Serdar Abac? Haluk Özyörük Attila Y?ld?z |
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| Affiliation: | (1) Department of Chemistry, Faculty of Science, Hacettepe University, 06532 Beytepe, Ankara, Turkey;(2) Analytical Chemistry Department, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey |
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| Abstract: | Poly(vinylferrocenium) (PVF+) modified gold (Au) electrode was developed in this study for the electrochemical sensing of deoxyribonucleic acid (DNA)
hybridization based on the oxidation signals of polymer and guanine, and also for the electrochemical investigation of interaction
of anticancer drug, mitomycin C (MC) and DNA immobilized onto PVF+ modified Au electrode. PVF+ modified Au electrode was prepared by electrooxidation of poly(vinylferrocene) PVF at +0.7 V versus Ag/AgCl reference electrode.
The polymer modified electrode and DNA immobilized polymer modified electrode were characterized by X-ray photoelectron (XPS),
Fourier transform infrared-attenuated total reflentance (FTIR-ATR) and alternating current (AC) impedance spectroscopy. For
application studies, differential pulse voltammetry (DPV) technique was used. |
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