Synthesis and in vitro bioactivity of novel mesoporous hollow bioactive glass microspheres |
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Authors: | Bo Lei Yingjun Wang Naru Zhao |
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Affiliation: | Biomaterials Research Institute, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, PR China The Key Laboratory of Specially Functional Materials, Ministry of Education, South China University of Technology, Guangzhou 510640, PR China |
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Abstract: | The remarkable tissue-repairing bioactivity and biocompatibility of bioactive glass make it suitable for a wide range of applications. Here, novel mesoporous hollow bioactive glass microspheres (MHBGMs) with a uniform diameter range of 2-5 µm were prepared by a sol-gel method. Structural characterization indicated that the shell of hollow sphere had a mesopore size range between 2 and 10 nm and a thickness about 500 nm. The in vitro bioactivity test indicated that the novel structure exhibited high in vitro bioactivity. The uniform microspherical morphology and mesoporous hollow structure of MHBGMs, together with their high bioactivity, turn them into a good candidate as an injectable and drug-loading biomaterial for in vivo tissue regeneration and drug control release. |
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Keywords: | Sol-gel preparation Sintering Hollow microspheres Bioactive glass Bioactivity Biomaterials |
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