副干酪乳杆菌TD062对Ⅱ型糖尿病小鼠的降糖作用

对Ⅱ型糖尿病小鼠分别灌胃109,108 CFU/mL和107 CFU/mL副干酪乳杆菌TD062,研究其对糖尿病小鼠的降糖作用。同时检测糖原合成酶激酶-3β(GSK-3β)基因的表达情况,探讨其降糖机制。试验结果表明,副干酪乳杆菌TD062可有效改善糖尿病小鼠血糖水平、脏器指数和体重,显著提高葡萄糖耐受性及抗氧化能力,并通过降低GSK-3β的相对基因表达量,调节糖尿病模型中糖代谢紊乱,改善胰岛素抵抗,从而有效预防糖尿病的发生,为功能性食品的开发提供理论依据。

Antidiabetic Effect of Lactobacillus paracasei TD062 on Type 2 Diabetes Mice

The objective of this study was to evaluate hypoglycemic effects of Lactobacillus paracasei TD062 on the type 2 diabetes mice treated with the strain at 109,108 and 107 CFU/mL.Meanwhile,the expression levels of glycogen synthase kinase 3β(GSK-3β)were determined to explore the hypoglycemic mechanism.The results demonstrated that L.paracasei TD062 could ameliorate glucose levels,organ coefficient and body weight.In addition,glucose tolerance and antioxidant capacity were elevated by oral administration of L.paracasei TD062.Furthermore,it was revealed that L.paracasei TD062 downregulated the relative expression levels of GSK-3β,regulated glucose metabolic disorders and ameliorated insulin resistance,thus delaying the development of diabetes.Therefore,L.paracasei TD062 might be applied as a new type of hypoglycemic agent in functional foods.