Kidney lipids: Changes caused by dietary 9-Trans, 12-Trans-octadecadienoate |
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Authors: | J E Kinsella P H Yu J B Mai |
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Affiliation: | (1) Institute of Food Science, Cornell University, 14853 Ithaca, NY |
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Abstract: | Trans, trans-linoleate at 50 and 100% of dietary fat decreased kidney size and altered its composition.Trans, trans-linoleate as the sole source of dietary fat imparied growth and caused more severe symptoms of essential fatty acid deficiency
than was observed with hydrogenated coconut oil (HCO). The concentration of renal cholesterol, phospholipids (PL), triglycerides
(TG) and cholesteryl esters (CE) were also decreased. Linoleic (18∶2), homo-γ-linolenic acid (20∶3n6) and arachidonic acid
(20∶4n6) were significantly depressed in lipid classes, especially in PL and CE, by dietarytrans, trans-linoleate. The increase in eicosatrienoate (20∶3n9), especially in PL and CE of kidneys of rats fed HCO (essential fatty
acid deficient), was slight in rats fed 100%trans, trans-linoleate, indicating that thetrans, trans acid probably inhibited acyl elongation and desaturation. |
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