| 伊潘立酮合成缩合反应的工艺改进 |
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| 引用本文： | 李陈.伊潘立酮合成缩合反应的工艺改进[J].辽宁化工,2011(8):783-784. |
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| 作者姓名： | 李陈 |
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| 作者单位： | 四川阳光润禾药业; |
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| 摘 要： | 通过对伊潘立酮关键缩合反应的工艺条件优化,最终确定的最佳反应工艺为：以6-氟-3-（4-哌啶基）-1,2-苯并异噁唑盐酸盐和1-4-（3-氯丙氧基）-3-甲氧苯基]乙酰酮为原料,乙腈为溶媒,碳酸钾为束酸剂,于74～81℃缩合成伊潘立酮;收率86.4%
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| 关 键 词： | 伊潘立酮 合成 工艺优化 |
Improvement of Condensation Process for Synthesizing Iloperidone |
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| LI Chen.Improvement of Condensation Process for Synthesizing Iloperidone[J].Liaoning Chemical Industry,2011(8):783-784. |
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| Authors: | LI Chen |
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| Affiliation: | LI Chen(Sichuan Sunheal Pharmaceutical Company Limited,Sichuan Chengdu 610041,China) |
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| Abstract: | By the technological optimization of condensation process for synthesizing Iloperidone,the optimum technology conditions were determined as follows： 6-Fluoro-3-（4-piperidine）-1,2-benzoisoxazole hydrochloride and 1-4-（3-chloropropoxy）-3-methoxyphenyl]ethanone were used as starting material,acetonitrile was used as solvent,potassium carbonate was used as acid trapping agent,the condensation reaction was carried out at 74～81 ℃,yield of product was 86.4%. |
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| Keywords: | Iloperidone Synthesis Process optimization |
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