In vitro concentration response studies and in vitro phase II tests as the experimental basis for regional chemotherapeutic protocols |
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Authors: | KH Link G Leder J Pillasch U Butzer L Staib M Kornmann U Bruckner HG Beger |
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Affiliation: | Centers for Disease Control and Prevention, Respiratory Diseases Laboratory Section, Atlanta, GA 30333, USA. |
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Abstract: | Two iron-regulated genes with deduced homology to TonB-dependent ferric siderophore receptors were cloned from Bordetella bronchiseptica by screening a library of TnphoA insertion mutants. bfrB and bfrC were iron-repressed in B. bronchiseptica by a Fur-dependent mechanism, and were expressed from promoters overlapped by potential Fur-binding sites. Both genes were highly conserved among Bordetella species and were also iron-regulated in Bordetella pertussis. bfrB and bfrC mutants of both species and a bfrB-bfrC double mutant of B. bronchiseptica had no discernible defects in utilization of known iron sources for Bordetella. |
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