膳食黑米皮对apoE基因缺陷小鼠胆固醇代谢的影响

研究膳食黑米对apoE基因缺陷小鼠胆固醇代谢的影响。探讨黑米皮抗动脉粥样硬化作用机制。在apoE基因缺陷小鼠饲料（AIN－93）中添加5％黑米皮，喂养小鼠16周后，检测小鼠血清，肝脏和主动脉中胆固醇的水平。黑米皮可降低血清，肝脏和主动脉中总胆固醇（TC）的含量，提高血清中高密度脂蛋白胆固醇（HDL－C）的含量，与白米皮相比具有显著性差异。膳食黑米皮可改善apoE基因缺陷小鼠胆固醇的代谢，而这可能是黑米皮抗As作用的机制之一。

Study on Effects of Dietary BRF on Cholesterol Metabolism of apoE - deficien t Mice to Inhibit Athelogenesis

To explore the effect of dietary black rice pericarp fraction(BRF)on cholesterol metabolism,and to elucidate the mechanismof BRF anti -atherogenesis in apoE -deficient mi ce.After16weeks feed by 5%BRF,cholesterol levels in serum,liver and aorta of different groups were determined by enzymatic method.The stu dy suggestedthatmiceinBRFfed grouphadlowertotalcholesterollevels in serum,liverandaorta incomparison with control WRF white rice pericarp fraction.At the same time,BRF group had h igher HDL -C level compared to controlgroup.Dietary BRFcouldinp rove cholesterolmetabolisminapoE-deficientmice andthis effectmigh tbe one of the possible mechanisms by whi ch BRFcould inhibit atherogenesis.