Chronic pancreatitis prevalence in liver cirrhosis. Morphological and functional study |
| |
Authors: | P Caradonna G Costamagna G Benedetti N Gentiloni GB Gasbarrini |
| |
Affiliation: | Institute of General Pathology, University of Verona, Italy. |
| |
Abstract: | In the present study we have examined the ability of the beta-amyloid peptide (A beta(25-35)) to modulate the respiratory burst activity of human monocytes in vitro. Incubation of the cells for 24 h with A beta(25-35) as well as with A beta(1-42) resulted in an enhanced production of reactive oxygen radicals (ROI) in response to phorbol 12-myristate 13-acetate (PMA). Such effect was additively increased by coincubation with interferon-gamma (IFN gamma), and was paralleled by modulation of gene and protein expression of some components of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system. Since the effects of A beta(25-35) were also reproduced in primary rat microglia, our findings indicate that A beta(25-35) can potentiate the ability of mononuclear phagocytes to produce ROI, and add further insights into its biological effects. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|