Recrystallization of phenylbutazone using supercritical fluid antisolvent process |
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Authors: | Su-Jin Park Sang-Do Yeo |
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Affiliation: | (1) Department of Chemical Engineering, Kyungpook National University, Daegu, 702-701, Korea |
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Abstract: | Phenylbutazone was recrystallized from its solutions by using a supercritical fluid antisolvent process. It was dissolved
in acetone and supercritical carbon dioxide was injected into the solution, thereby inducing supersaturation and particle
formation. Variation in the physical properties of the recrystallized phenylbutazone was investigated as a function of the
crystallizing temperature and the carbon dioxide injection rate. The recrystallized particles showed cleaner surfaces and
more ordered morphology compared to the particles obtained by other methods such as solvent evaporation. X-ray diffraction
patterns indicated that the crystallinity of the particles had been modified upon the recrystallization. Differential scanning
calorimetry measurement revealed that the crystallizing temperature influenced the thermal stability of the resulting crystals.
Larger crystals were produced when the carbon dioxide injection rate was reduced. |
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Keywords: | Antisolvent Nucleation Phenylbutazone Recrystallization Supersaturation |
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