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Anti-tumor activity of self-charged (Eu,Ca):WO3 and Eu:CaWO4 nanoparticles |
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| Authors: | CAO LIN CAO JIEXIN WANG CONG CHE PING PAN DE’AN ALEX A VOLINSKY |
| Affiliation: | 1. Department of Materials Physics, University of Science and Technology Beijing, Beijing, 100083, China 2. Peking University Health Science Centre, Beijing, 100191, China 3. School of Applied Science, University of Science and Technology Beijing, Beijing, 100083, China 4. Department of Mechanical Engineering, University of South Florida, Tampa FL, 33620, USA |
| Abstract: | Non-stoichiometric (Eu,Ca):WO3 and Eu:CaWO4 nanoparticles with anti-tumor activity are synthesized in a sol?Cgel method by adding excessive Eu3?+? and Ca2?+? ions to tungsten oxide crystal structure. Colorimetric assay shows that 10?nm (Eu,Ca):WO3 and Eu:CaWO4 nanoparticles can effectively inhibit growth of mammary cancer cells without any harm to normal cells. Nanoparticles are characterized by X-ray diffraction, high resolution transmission electron microscopy and fluorescence optical spectrometry. Nanomaterials, insoluble in synthesized water, have complicated self-charging surfaces that trap mammary cancer cells. Surface self-charging effect is suggested as the inhibition mechanism. |
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