亚麻籽油对小鼠免疫功能的影响

分别以0.15、0.05、0.025 g/mL的亚麻籽油作为高、中、低剂量组，按10 mL/（kg·d）给予小鼠30 d灌胃试验，分析测定小鼠体重、脏体比（胸腺指数、脾指数）、细胞免疫功能（小鼠淋巴细胞转化试验，迟发型变态反应试验）、体液免疫功能（抗体生成细胞试验，血清溶血素测定试验）、单核-巨噬细胞功能（碳廓清试验，腹腔巨噬细胞吞噬鸡红细胞试验）和NK细胞活性，以考察亚麻籽油对小鼠免疫功能的影响。结果表明：亚麻籽油对小鼠的体重、脏体比、血清溶血素以及单核-巨噬细胞功能无显著影响（P＞0.05）；与对照组比较，中剂量组和高剂量组能够显著提高小鼠的细胞免疫功能（淋巴细胞转化，迟发型变态反应）和NK细胞活性（P＜0.05）。研究结果说明亚麻籽油对小鼠具有增强免疫力的功能。

Effect of flaxseed oil on immune function of mice

The flaxseed oil with the mass concentration of 0.15, 0.05, 0.025 g/mL was used as high, medium and low dose groups to give mice by intragastric administration with 10 mL/(kg·d) for 30 d, then the weight, ratio of organ weight to body weight (thymus index, spleen index), cellular immune function (mice lymphocyte transformation test, delayed type hypersensitivity test), humoral immune function (antibody-producing cell test, serum hemolysin determination test), monocytes-macrophages function (carbon clearance test, phagocytosis of peritoneal macrophages test) and NK cell activity were determined to investigate the effect of flaxseed oil on the immune function of mice. The results showed that flaxseed oil had no significant effect on the body weight, ratio of organ weight to body weight, serum hemolysin and monocytes-macrophages function of mice(P>0.05). Compared with the control group, the medium dose group and high dose group could significantly increase the cellular immune function (lymphocyte transformation, delayed type hypersensitivity) and NK cell activity (P<0.05). The results indicated that flaxseed oil had the function of enhancing immunity of mice.