海豹油对高脂血症大鼠和正常大鼠血脂的影响

分别建立高胆固醇血症和高甘油三酯血症大鼠模型,经口给予海豹油,研究海豹油对两种模型大鼠血脂的干预作用,同时研究海豹油对正常大鼠血脂的影响。结果表明:对于高胆固醇血症大鼠,海豹油降低了大鼠血清TG、TC和LDL-C含量,高剂量组(0.67 g/kg)大鼠血清HDL-C含量显著升高(p <0.05),各剂量组大鼠血清HDL-C与TC比值均极显著升高(p <0.01);对于高甘油三酯血症大鼠,海豹油降低了大鼠血清TG和TC含量,并使血清HDL-C与TC比值极显著升高(p <0.01);对于正常饲养的大鼠,海豹油对大鼠的体重、食物利用率、脏器系数以及血清生化指标均无显著影响。综上,经口给予高胆固醇血症或高甘油三酯血症大鼠海豹油,可有效降低两种模型大鼠血清TC和TG含量,而经口给予正常饲养大鼠海豹油,不会对正常大鼠的体重、摄食、血清生化指标以及各种脏器造成影响。

Effect of seal oil on blood lipids in hyperlipidemia and normal rats

Rat models of hypercholesterolemia and hypertriglyceridemia were established,and seal oil was administered orally to study the intervention effect of seal oil on the blood lipids of the two model rats. In addition,the effect of seal oil on the blood lipids of normal rats was studied. The results showed that for hypercholesterolemia rats,seal oil could reduce the TG,TC and LDL-C levels and significantly increase the ratio of HDL-C to TC (p < 0. 01) in rats,and the HDL-C level significantly increased (p < 0. 05)in the high-dose group (0. 67 g/kg) rats;for hypertriglyceridemia rats,seal oil could reduce the TG and TC levels and significantly increase the ratio of HDL-C to TC (p < 0. 01) in rats;for normally fed rats,seal oil had no significant effect on the body weight,food utilization rate,organ coefficient and serum biochemical indexes of the rats. In summary,oral administration of seal oil to hypercholesterolemia or hypertriglyceridemia rats could effectively reduce the TC and TG levels in the two model rats,while oral administration of seal oil to normal rats had no effect on the body weight,food intake,serum biochemical indexes and various organs of normal rats.