Intracellular translocation and stability of apolipoprotein B are inversely proportional to the length of the nascent polypeptide |
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| Authors: | D Cavallo RS McLeod D Rudy A Aiton Z Yao K Adeli |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada N9B 3P4. |
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| Abstract: | We have studied the relationship between the length of apolipoprotein B (apoB) and its intracellular translocation and stability using McArdle RH7777 (McA-RH7777) cells expressing recombinant human apoB variants, ranging in size from B15 to B100. The translocational status of apoB was assessed based on trypsin sensitivity of apoB using isolated microsomes as well as permeabilized cells. In isolated microsomes, shorter apoB variants (
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