| 单细胞结构和电学特征检测方法 |
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| 引用本文： | 梁红雁,陈德勇,王军波,陈健.单细胞结构和电学特征检测方法[J].电子与信息学报,2022,44(8):2966-2976. |
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| 作者姓名： | 梁红雁 陈德勇 王军波 陈健 |
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| 作者单位： | 1.中国科学院空天信息创新研究院传感技术国家重点实验室 北京 1001902.中国科学院大学电子电气与通信工程学院 北京 1000493.中国科学院大学未来技术学院 北京 100049 |
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| 基金项目： | 国家自然科学基金(61825107, 61922079, 62121003) |
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| 摘 要： | 单细胞固有生物物理学特征，主要包括结构特征如细胞直径和细胞核直径，以及电学特征如细胞膜比电容和细胞质电导率，已经被应用于细胞亚类型分类和细胞状态评估，在生物医学研究和临床诊断方面具有广阔的应用前景。该文综述了不同类型的单细胞结构和电学特征检测方法，介绍了固定式、流动式以及基于微流控的方法。归纳总结了这些方法的工作原理、发展和主要优缺点，探讨了单细胞结构和电学特征检测所面临的挑战以及未来的研究机遇。
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| 关 键 词： | 单细胞分析 结构特征 电学特征 微流控 |
| 收稿时间： | 2021-12-08 |
Methods for Measuring Single-Cell Structural and Electrical Properties |
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| LIANG Hongyan,CHEN Deyong,WANG Junbo,CHEN Jian.Methods for Measuring Single-Cell Structural and Electrical Properties[J].Journal of Electronics & Information Technology,2022,44(8):2966-2976. |
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| Authors: | LIANG Hongyan CHEN Deyong WANG Junbo CHEN Jian |
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| Affiliation: | 1.State Key Laboratory of Transducer Technology, Aerospace Information Research Institute of Chinese Academy of Sciences, Beijing 100190, China2.School of Electronic, Electrical and Communication Engineering of University of Chinese Academy of Sciences, Beijing 100049, China3.School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China |
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| Abstract: | Single-cell intrinsic biophysical properties including structural properties (e.g., cellular diameter and nuclear diameter) and electrical properties (e.g., specific membrane capacitance and cytoplasmic conductivity) have been applied to cell subtype classifications, and cell status evaluations are promising in biomedical research and clinical diagnosis. Different types of single-cell structural and electrical properties detection methods are reviewed in this paper, then fixed and flow methods and microfluidic methods are introduced. The working principles, developments, main advantages and disadvantages of these methods are summarized, and the challenges and future research opportunities for measurements of single-cell structural and electrical properties are discussed. |
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