| 胶原蛋白结构和稳定性关系研究 |
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| 引用本文： | 李卫林,曹健,汤克勇,左锦静,王岩. 胶原蛋白结构和稳定性关系研究[J]. 中国皮革, 2005, 34(23): 14-16 |
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| 作者姓名： | 李卫林 曹健 汤克勇 左锦静 王岩 |
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| 作者单位： | 1. 河南工业大学生物工程系,郑州,450052
2. 郑州大学材料工程学院,郑州,450052 |
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| 基金项目： | 国家自然科学基金(20174037)资助计划项目 |
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| 摘 要： | 胶原蛋白由重复出现的Gly-X-Y三肽段构成,X位和Y位的氨基酸序列以及Gly在肽链中的重复出现,都是导致胶原蛋白高稳定性的原因。某些特殊氨基酸以及氨基酸的空间构象和各种分子间力,也起着共同维持胶原蛋白稳定性的作用。从胶原结构上探讨了氨基酸排列对胶原蛋白稳定性的影响。
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| 关 键 词： | 胶原蛋白 Gly-X-Y三肽段 氨基酸序列 分子间力 稳定性 |
| 修稿时间： | 2005-01-18 |
Study on relationship between collagen structure and its stability |
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| Li Weilin,Cao Jian,Tang Keyong,Zuo Jinjing,Wang Yan. Study on relationship between collagen structure and its stability[J]. China Leather, 2005, 34(23): 14-16 |
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| Authors: | Li Weilin Cao Jian Tang Keyong Zuo Jinjing Wang Yan |
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| Affiliation: | Li Weilin 1,Cao Jian 1,Tang Keyong 2,Zuo Jinjing 1,Wang Yan 1 [WT12.HZ] |
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| Abstract: | Collagen is constituted by repeated triplet of Gly-X-Y. The amino acid sequences in position of X and Y, as well as the repeated Gly-X-Y, lead to the high stability of collagen. Companying with the intermolecular interactions, some specific amino acid and the space conformations of amino acid play a role in maintaining the stability of triple-helix of collagen. The influence of amino acids sequence to stability of collagen was discussed in this article from the view of structure. |
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| Keywords: | collagen Gly-X-Y triplet amino acid sequence intermolecular interaction stability |
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