| 碳酸钾催化从烯酮二硫缩醛合成多取代嘧啶 |
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| 引用本文： | 余申义,魏朝俊,李明磊. 碳酸钾催化从烯酮二硫缩醛合成多取代嘧啶[J]. 化学试剂, 2005, 27(7): 429-430 |
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| 作者姓名： | 余申义 魏朝俊 李明磊 |
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| 作者单位： | 北京化工大学,化学系,北京,100029;北京化工大学,化学系,北京,100029;北京化工大学,化学系,北京,100029 |
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| 摘 要： | 以2-氰基-3，3-二甲硫基丙烯腈和5-烷基异硫脲盐为原料，在无水碳酸钾催化下较高收率得到5-氰基-4-氨基-2，6-二烷硫基嘧啶化合物，平均产率86．4％，最高产率达96．7％。
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| 关 键 词： | 无水碳酸钾 嘧啶 合成 |
| 文章编号： | 0258-3283(2005)07-0429-02 |
Synthesis of polysubstituted pyrimidine from ketene dithioacetals by using K2CO3 catalyst |
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| YU Shen-yi,WEI Chao-jun,LI Ming-lei. Synthesis of polysubstituted pyrimidine from ketene dithioacetals by using K2CO3 catalyst[J]. Chemical Reagents, 2005, 27(7): 429-430 |
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| Authors: | YU Shen-yi WEI Chao-jun LI Ming-lei |
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| Affiliation: | YU Shen-yi~*,WEI Chao-jun,LI Ming-lei |
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| Abstract: | K_2CO_3 was used to catalyze the synthesis of 2-alkylthio-4-amino-5-cyano-6-methylthiopyrimidines by the reaction of the ketene dithioacetals prepared from malononitrile with isothiuronium salts.Six pyrimidine compounds were synthesized.The separation yield reached 96.7%.The reaction conditions were researched including solvents and the catalyst amounts. |
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| Keywords: | anhydrous potassium carbonate polysubstituted pyrimidine synthesis |
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