| N-丙基-4-哌啶酮的合成研究 |
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| 引用本文： | 郑阳峰,洪志,蒋华江. N-丙基-4-哌啶酮的合成研究[J]. 浙江化工, 2007, 38(9): 14-15 |
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| 作者姓名： | 郑阳峰 洪志 蒋华江 |
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| 作者单位： | 台州学院医药化工学院,浙江,临海,317000 |
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| 摘 要： | 以丙烯酸甲酯和丙胺为原料，经过Michael加成，Dieckmann缩合和水解脱羧反应，简便、高效地合成了N-丙基-4-哌啶酮。分别对原料配比、合成过程等方面进行了改进，简化了合成工艺，节省了原料和成本，更适合于大规模生产。产品经过核磁氢谱检测表征，而且也经过气相色谱检测，具有很高的纯度。
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| 关 键 词： | N-丙基-4-哌啶酮 Michel加成 Dieckmann缩合 水解脱羧 合成 |
| 文章编号： | 1006-4184（2007）09-0014-02 |
| 修稿时间： | 2007-05-28 |
Study on the Synthesis of N-Propyl-4-piperidone |
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| ZHENG Yang-feng,HONG Zhi,JIANG Hua-jiang. Study on the Synthesis of N-Propyl-4-piperidone[J]. Zhejiang Chemical Industry, 2007, 38(9): 14-15 |
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| Authors: | ZHENG Yang-feng HONG Zhi JIANG Hua-jiang |
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| Affiliation: | Department of Chemical, Taizhou University, Linhai, Zhejiang 317000, China |
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| Abstract: | N-Propyl-piperidone was synthesized with propylamine and methyl acrylate as raw materials via a series of Michael addition, Dieckmann condensation and hydrolysis decarboxylation reactions. The proportion of materials and the synthetic condition were optimized. The product was characterized by elemental analysis, GC and ^1H NMR. |
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| Keywords: | N-propyl-piperidone michael addition dieckmann condensation hydrolysis decarboxylation reaction synthesis |
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