人参水溶性膳食纤维对大鼠糖脂代谢、氧化应激和肠道健康的影响

目的:研究人参水溶性膳食纤维对健康大鼠糖脂代谢、氧化应激和肠道健康的影响.方法:向SD大鼠连续灌胃人参水溶性膳食纤维15 d,对照组给予等体积生理盐水,分析大鼠生长情况、代谢水平和肠道菌群结构变化.结果:人参水溶性膳食纤维能够极显著提高大鼠采食量(P＜0.01),但对体质量增长率、饲料利用率及脏器指数无显著影响(P＞0...

Effect of Ginseng Water-Soluble Dietary Fiber on Glucolipid Metabolism,Oxidative Stress and Intestinal Health in Rats

Purpose: To investigate the effect of ginseng water-soluble dietary fiber (GSDF) on glucolipid metabolism and intestinal health in rats. Methods: SD rats were gavaged with GSDF or an equal volume of normal saline as a control for 15 days, and they were evaluated for growth performance, metabolism level and intestinal flora structure. Results: GSDF could significantly increase the feed intake of rats (P < 0.01), but had no significant effect on percent body mass gain, feed utilization rate or visceral organ indexes (P > 0.05). Low-dose GSDF significantly increased fasting insulin level (P < 0.05), and decreased total cholesterol level (P < 0.05). High-dose GSDF significantly reduced fasting blood glucose (P < 0.05) and total triglyceride level (P < 0.01). GSDF significantly reduced serum malondialdehyde content (P < 0.01), and improved total antioxidant capacity (P < 0.01). Low-dose GSDF significantly reduced the inflammatory factor levels including tumor necrosis factor α (P < 0.01), interleukin (IL) 1β (P < 0.05) and IL-4 (P < 0.01), and increased fecal water content (P < 0.05). Moreover, GSDF increased the abundance of intestinal Firmicutes and Lactobacillus, changing the structure of intestinal flora in the direction of enriching probiotics and cellulose-degrading bacteria, and affected the functional gene expression of related metabolic pathways. Conclusion: GSDF exerts a positive effect on rats by regulating growth metabolism, oxidative stress status and intestinal flora structure.