群体感应抑制剂调控食源性微生物生物膜形成的研究进展

食源性微生物的生物膜是附着在固体表面上形成的具有空间组织的群落，因其能够附着在食品工业环境中的生物或非生物表面，且对消毒剂和抗菌剂能产生抗药性，通常难以控制，被认为是造成设备损坏、能源成本增加、食物变质和引起食源性疾病的原因之一，给食品工业带来了巨大的挑战。研究发现群体感应在生物膜的形成中起至关重要的作用，可以通过阻断群体感应系统来控制生物膜的形成。因此，群体感应抑制剂可以作为控制生物膜形成的新策略，在食品工业中对控制生物膜的形成具有巨大潜力。本文综述了生物膜的形成、群体感应系统及其对生物膜的调控作用，介绍了群体感应抑制剂的调控机制及其分类，为通过群体感应抑制剂调控生物被膜的形成提供研究思路。

Progress in Quorum Sensing Inhibitors in Regulating Biofilm Formation of Foodborne Microorganisms

The biofilm of foodborne microorganisms is a community that is spatially organized and attaches to solid surfaces. Its attachment to biotic or abiotic surfaces in the food industry environment renders resistance to disinfectants and antibacterial agents, making it difficult to control biofilm formation. This phenomenon is considered a cause of food processing equipment damage, increased energy consumption and costs, food quality deterioration and foodborne diseases, bringing great challenges to the food industry. It has been found that quorum sensing plays a paramount role in biofilm formation, which can be controlled by blocking the quorum sensing system. Therefore, quorum sensing inhibitors can be used as a new strategy to control biofilm formation and possess great potential for application in the food industry. In the present article, the biofilm formation of foodborne microorganisms, quorum sensing system and its regulation on the biofilm formation are reviewed. Meanwhile, the regulation mechanism and classification of quorum sensing inhibitors are discussed. We hope that this review can provide useful information for regulating the biofilm formation of foodborne microorganisms through quorum sensing inhibitors.