| 乳铁蛋白对炎症性肠炎大鼠肠道微生态的正向调节作用 |
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| 引用本文： | 赵晓,徐境含,崔东影,徐珒昭,刘洋,滕国新,许晓曦. 乳铁蛋白对炎症性肠炎大鼠肠道微生态的正向调节作用[J]. 食品科学, 2021, 42(13): 136-142. DOI: 10.7506/spkx1002-6630-20200715-210 |
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| 作者姓名： | 赵晓 徐境含 崔东影 徐珒昭 刘洋 滕国新 许晓曦 |
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| 作者单位： | （1.东北农业大学食品学院,黑龙江 哈尔滨 150030;2.武警工程大学装备管理与保障学院,陕西 西安 710086;3.黑龙江飞鹤乳业有限公司,北京 100015;4.内蒙古蒙牛乳业（集团）股份有限公司,内蒙古 呼和浩特 011500） |
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| 基金项目： | 内蒙古自治区科技成果转化项目（CGZH2018035） |
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| 摘 要： | 本研究采用葡聚糖硫酸钠(dextran sulphate sodium,DSS)刺激以构建SD大鼠炎症性肠炎(inflammatory bowel disease,IBD)模型,通过高通量测序分析乳铁蛋白(lactoferrin,LF)对大鼠结肠粪便肠道菌群α-多样性、物种差异性分布、KEGG信号通路相关操作分类单元(...
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| 关 键 词： | 乳铁蛋白 肠道菌群 炎症性肠炎 SD大鼠 KEGG信号通路 |
Positive Regulation of Lactoferrin on Gut Micro-Ecology of Rats with Inflammatory Bowel Disease |
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| ZHAO Xiao,XU Jinghan,CUI Dongying,XU Jinzhao,LIU Yang,TENG Guoxin,XU Xiaoxi. Positive Regulation of Lactoferrin on Gut Micro-Ecology of Rats with Inflammatory Bowel Disease[J]. Food Science, 2021, 42(13): 136-142. DOI: 10.7506/spkx1002-6630-20200715-210 |
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| Authors: | ZHAO Xiao XU Jinghan CUI Dongying XU Jinzhao LIU Yang TENG Guoxin XU Xiaoxi |
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| Affiliation: | (1. School of Food Science, Northeast Agricultural University, Harbin 150030, China; 2. Institute Equipment Management and Support, Engineering University of Peoples Armed Police Force, Xi’an 710086, China; 3. Heilongjiang Feihe Dairy Co., Ltd., Beijing 100015, China; 4. Inner Mongolia Mengniu Dairy Industry (Group) Co., Ltd., Hohhot 011500, China) |
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| Abstract: | The effect of lactoferrin (LF) on the α-diversity and composition, as well as the abundance of KEGG signaling pathway-related operational taxonomic unit (OTU) in the colonic microbiota of rats with inflammatory bowel disease (IBD) induced by dextran sulphate sodium (DSS) was analyzed by high-throughput sequencing. The results showed that LF alleviated the reduction of α-diversity and the imbalance between the dominant phyla Firmicutes and Bacteroidetes caused by DSS stimulation. LF increased the abundance of Lactobacillaceae (12% vs. 40%) and Ruminococcaceae (17% vs. 27%), and decreased Bacteroides (28% vs. 8%) and Prevotellaceae (13% vs. 6%). LF administration reduced the abundance of OTUs associated with human diseases such as cancer and infectious diseases, immune system, cells and genetics-related signaling pathways in the gut microbiota in IBD rats. The results of this study indicated that LF can play a beneficial role in regulating the colonic micro-ecology of IBD rats and modulating the microbiota composition to be similar to that of healthy rats, thereby having the potential to reduce the risk of other concomitant diseases. |
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| Keywords: | lactoferrin gut microbiota inflammatory bowel disease SD rats KEGG signaling pathway, |
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