| 紫穗槐蜂蜜对小鼠急性酒精性胃溃疡的预防作用 |
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| 引用本文： | 祝敏,靳林,赵浩安,王倩,张锦锦,杨二林,曹炜. 紫穗槐蜂蜜对小鼠急性酒精性胃溃疡的预防作用[J]. 食品科学, 2021, 42(9): 77-84. DOI: 10.7506/spkx1002-6630-20200616-207 |
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| 作者姓名： | 祝敏 靳林 赵浩安 王倩 张锦锦 杨二林 曹炜 |
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| 作者单位： | （1.西北大学化工学院，陕西 西安 710069；2.陕西省国营林场管理站（陕西省林业产业发展中心），陕西 西安 710082；3.西北大学食品科学与工程学院，陕西 西安 710069；4.陕西省蜂产品工程技术研究中心，陕西 西安 710065） |
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| 基金项目： | 国家自然科学基金面上项目（31871876）；陕西省林业科学研究重大专项（2017-01）；陕西省科技厅重点研发计划项目（2018FP2-03） |
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| 摘 要： | 为研究紫穗槐蜂蜜对小鼠急性酒精性胃溃疡的预防作用,本实验采用紫穗槐蜂蜜对小鼠连续灌胃10?d,随后通过灌胃体积分数65％的乙醇溶液诱导小鼠急性酒精性胃溃疡损伤.通过观察小鼠胃组织病理结构、测定溃疡指数,分析紫穗槐蜂蜜对小鼠胃组织的保护作用;通过测定氧化应激和炎症因子相关生化指标,评价紫穗槐蜂蜜对急性酒精性胃溃疡小鼠胃组...
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| 关 键 词： | 紫穗槐蜂蜜 急性酒精性胃溃疡 氧化应激 预防作用 |
Gastroprotective Effect of Amorpha fruticosa L. Honey against Ethanol-Induced Acute Gastric Ulcer in Mice |
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| ZHU Min,JIN Lin,ZHAO Hao’an,WANG Qian,ZHANG Jinjin,YANG Erlin,CAO Wei. Gastroprotective Effect of Amorpha fruticosa L. Honey against Ethanol-Induced Acute Gastric Ulcer in Mice[J]. Food Science, 2021, 42(9): 77-84. DOI: 10.7506/spkx1002-6630-20200616-207 |
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| Authors: | ZHU Min JIN Lin ZHAO Hao’an WANG Qian ZHANG Jinjin YANG Erlin CAO Wei |
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| Affiliation: | (1. School of Chemical Engineering, Northwest University, Xi’an 710069, China; 2. Forest Farm Management Station of Shaanxi Province (Forest Industry Development Center of Shaanxi Province), Xi’an 710082, China; 3. College of Food Science and Technology, Northwest University, Xi’an 710069, China; 4. Bee Product Research Center of Shaanxi Province, Xi’an 710065, China) |
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| Abstract: | To estimate the gastroprotective effect of Amorpha fruticosa L. honey (AFH) against ethanol-induced acute gastric ulcer, mice pretreated with AFH via oral gavage for 10 days were administered with 65% ethanol to induce acute gastric ulcer injury. The effect of AFH on the gastric pathological morphology and ulcer index of mice was analyzed, and its effect on gastric antioxidant and anti-inflammatory capacity in mice with acute alcoholic gastric ulcer was explored by the determination of biochemical indexes of oxidative stress and inflammatory cytokines. The results revealed that AFH protected the integrity of gastric mucosa, and alleviated the decrease in superoxide dismutase activity and glutathione content as well as the accumulation of malondialdehyde caused by ethanol consumption significantly (P < 0.05). Compared with the model control group, the AFH-treated mice showed significantly higher contents of prostaglandin E2 and NO (P < 0.05), but significantly lower content of tumor necrosis factor α in the gastric tissue (P < 0.05). The results of polymerase chain reaction and immunohistochemical analysis revealed that AFH significantly down-regulated the gene and protein expression of ulcer-related pro-inflammatory cytokines (P < 0.05). Taken together, AFH has a potential gastroprotective effect on ethanol-induced gastric ulcer by protecting the gastric mucosa from ethanol-induced damage and regulating oxidative stress and the expression of inflammatory cytokines. |
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| Keywords: | Amorpha fruticosa L. honey ethanol-induced acute gastric ulcer oxidative stress preventive effect, |
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