| 新型植物基载体对乳糖酶的高效递送及保护 |
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| 引用本文： | 侯欣尧,邓紫玙,梁宏闪,李斌. 新型植物基载体对乳糖酶的高效递送及保护[J]. 食品科学, 2021, 42(14): 137-143. DOI: 10.7506/spkx1002-6630-20200512-129 |
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| 作者姓名： | 侯欣尧 邓紫玙 梁宏闪 李斌 |
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| 作者单位： | （1.华中农业大学食品科技学院,湖北 武汉 430070;2.环境食品学教育部重点实验室,湖北 武汉 430070;3.湖北省功能食品工程技术研究中心,湖北 武汉 430068） |
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| 基金项目： | 湖北省大学生创新创业训练计划项目（S201910504068）;中央高校基本科研业务费专项（2662018QD016） |
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| 摘 要： | 为解决口服酶制剂易被胃液的强酸环境破坏其效价,影响乳糖不耐受症治疗效果的问题,制备一种可以保护乳糖酶过胃而不失去活性的新型植物基载体.采用新型植物基材料向日葵孢粉素外壁胶囊为载体,用于乳糖酶的负载及保护.通过负载、包膜、释放等实验以及采用扫描电子显微镜、激光共聚焦显微镜等表征手段,确定5％海藻酸钠与6％羧甲基茯苓多糖在...
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| 关 键 词： | 乳糖不耐受症 乳糖酶 孢粉素外壁胶囊 递送 保护 |
New Plant-based Carrier for Efficient Delivery and Protection of Lactase |
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| HOU Xinyao,DENG Ziyu,LIANG Hongshan,LI Bin. New Plant-based Carrier for Efficient Delivery and Protection of Lactase[J]. Food Science, 2021, 42(14): 137-143. DOI: 10.7506/spkx1002-6630-20200512-129 |
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| Authors: | HOU Xinyao DENG Ziyu LIANG Hongshan LI Bin |
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| Affiliation: | (1. College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; 2. Key Laboratory of Environment Correlative Dietology, Ministry of Education, Wuhan 430070, China; 3. Functional Food Engineering & Technology Research Center of Hubei Province, Wuhan 430068, China) |
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| Abstract: | The potency of traditional oral enzyme preparations for treating lactose intolerance can be readily impaired by the strong acidic environment in the stomach. In order to overcome this problem, sun?ower sporopollenin exine capsules (SECs), a new plant-based carrier that can protect lactase from losing its activity, were prepared for use as a carrier for loading and protection of lactase. Loading, encapsulation and release experiments and observation by scanning electron microscopy (SEM) and laser confocal microscopy (LCM) showed that gel microspheres of sodium alginate (5%) and carboxymethylpachymaran (6%) at a mixing ratio of 1:1 (V/V) gave the best release performance in vitro, allowing responsive release of lactase in simulated digestive fluids. The following experiments illustrated that this system also showed the potential as a freeze-drying protective agent for lactase. Based on this, this study successfully demonstrated the feasibility of SECs as an efficient delivery and protection carrier for lactase, which will provide a new idea for the treatment of lactose intolerance. |
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| Keywords: | lactose intolerance lactase sporopollenin exine capsules delivery protection, |
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