脱氧雪腐镰刀菌烯醇解毒酶研究进展

脱氧雪腐镰刀菌烯醇（Deoxynivalenol, DON）是镰刀菌属（Fusariums spp.）产生的剧毒次级代谢产物，主要污染小麦、玉米等粮食及其制品，导致了严重的食品安全风险。目前生物酶法去除DON的技术研究，展现出良好的应用前景。综述了国内外关于DON生物转化的生物酶类型、降解机制、产物结构特征、解毒酶挖掘策略，以及解毒酶分子改造等研究现状，并对人工智能应用于真菌毒素解毒酶的相关研究进行了展望，以期为食品和饲料中DON的生物脱毒技术的研发提供参考。

Research Advances in Enzymatic Detoxification of Deoxynivalenol

Deoxynivalenol (DON) is a toxic secondary metabolite produced by Fusarium spp. that mainly contaminates wheat, corn, and other food crops, and has posed serious threats to food safety. Currently, enzymatic detoxification of DON shows promising application prospects. This paper provided an overview of the latest domestic and international research on the types of biotransformation enzymes, degradation mechanisms, structural features, detoxification enzyme mining strategies, and molecular modifications of DON. Additionally, the paper explored research trends in molecular design of mycotoxin detoxification enzymes assisted by artificial intelligence, which aimed to provide a reference for the development of bio-detoxification technology of DON in food and feed.