| 液质联用法测定常用18F药物中Kryptofix2.2.2的含量 |
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| 引用本文： | 张晓军,李云刚,刘健,张锦明,田嘉禾.液质联用法测定常用18F药物中Kryptofix2.2.2的含量[J].同位素,2011,23(3):188-192. |
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| 作者姓名： | 张晓军 李云刚 刘健 张锦明 田嘉禾 |
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| 作者单位： | 解放军总医院 核医学科，北京100853 |
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| 基金项目： | 十一五国家支撑计划(2008BAI55B00) |
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| 摘 要： | 利用液质联用法定量分析了常用18F药物中Kryptofix 2.2.2(K2.2.2)的含量.选择母离子为(M+H)+377.4,使用合适的多反应监测离子对方法(MRM),建立了定量范围为20～500μg/L的K2.2.2标准曲线,线性相关系数为0.999 9,系统回收率和精密度均符合要求.利用此方法测量常规制备的18...
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| 关 键 词： | 液质联用 18F药物 K2.2.2含量 |
Measurement of Kryptofix 2.2.2 in ~(18)F-radiopharmaceuticals by LC/MS/MS |
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| ZHANG Xiao-jun,LI Yun-gang,LIU Jian,ZHANG Jin-ming,TIAN Jia-he.Measurement of Kryptofix 2.2.2 in ~(18)F-radiopharmaceuticals by LC/MS/MS[J].Isotopes,2011,23(3):188-192. |
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| Authors: | ZHANG Xiao-jun LI Yun-gang LIU Jian ZHANG Jin-ming TIAN Jia-he |
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| Affiliation: | Department Nuclear Medicine，the PLA General Hospital， Beijing 100853， China |
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| Abstract: | A high-performance liquid chromatography-tandem mass spectrometric method(LC/MS/MS) was used to quantify Kryptofix 2.2.2(K2.2.2) in 18F-FDG and 18F-FLT and other 18F-radiopharmaceuticals.First molecular ion peak m/z 377.4 + were detected by full scan mode,then the daughter ions 114.1,289.4 and 333.5 m/z were detected by product ion scan mode,the mass scanning mode was set to multiple reaction monitoring(MRM) and programmed to monitor the transitions of the parent/daughter ion pairs of 377.4/114.1,377.4/289.... |
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| Keywords: | LC/MS/MS 18F-radiopharmaceuticals conceneration of Kryptofix 2 2 2 |
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