| (N-[18F]氟甲基)胆碱的半自动合成和无菌型炎症PET显像评价 |
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| 引用本文： | 王红亮,黄婷婷,梁祥,吴克宁,唐刚华.(N-[18F]氟甲基)胆碱的半自动合成和无菌型炎症PET显像评价[J].同位素,2011,24(4):198-204. |
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| 作者姓名： | 王红亮 黄婷婷 梁祥 吴克宁 唐刚华 |
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| 作者单位： | 中山大学附属第一医院 核医学科PET-CT中心，广东 广州510080 |
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| 基金项目： | 国家高科技计划(863计划)专题课题(2008AA02Z430); 国际原子能机构资助项目(15245/RO) |
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| 摘 要： | 通过对现有的合成模块进行改进，实现了(N-18F]氟甲基)胆碱（18F-FCH）的半自动合成，并用其进行了无菌型炎症PET显像。以CH2Br2为前体，经过氟化反应制备甲基化试剂18FCH2Br，在柱与N, N-二甲基乙醇胺进行反应，并经过Sep Pak tC18和Sep Pak CM小柱联用纯化的方法，得到放化纯度大于95%的18F-FCH注射液，放化产率为12%±2%（n=3，按18F-计算，未校正），放化合成时间为35 min。PET显像表明，肌肉注射0.2 mL松节油，4天后形成的炎症模型具有18F-FDG最高摄取，而18F-FCH在炎症处具有轻度的放射性浓聚，因此在18F-FCH肿瘤显像时应考虑炎症的可能性。
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| 关 键 词： | [18F]氟甲基胆碱 炎症 18F-FDG PET显像 |
Semi-automatic Synthesis and PET Imaging Evaluation of ~(18)F-fluoromethylcholine With the Aseptic Inflammation Model |
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| WANG Hong-liang,HUANG Ting-ting,LIANG Xiang,WU Ke-ning,TANG Gang-hua.Semi-automatic Synthesis and PET Imaging Evaluation of ~(18)F-fluoromethylcholine With the Aseptic Inflammation Model[J].Isotopes,2011,24(4):198-204. |
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| Authors: | WANG Hong-liang HUANG Ting-ting LIANG Xiang WU Ke-ning TANG Gang-hua |
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| Affiliation: | PET-CT Center, Department of Nuclear Medicine, the First Affiliated Hospital,Sun Yat-sen University, Guangzhou 510080, China |
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| Abstract: | Semi-automated synthesis of 18F-fluoromethylcholine(18F-FCH) was achieved with the modification of the commercial synthesis model and the PET imaging of aseptic inflammation model was performed with 18F-FCH.18FCH2Br as a fluoromethylation agent was prepared by the fluorination of dibromomethane followed by distillation from the reaction vessel.The obtained 18FCH2Br then reacted with N,N-dimethylamino ethanol loaded on the Sep Pak tC18 cartridge to give 18F-FCH.After being purified on the solid-phase extract... |
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| Keywords: | 18F-fluoromethylcholine(18F-FCH) inflammation 18F-FDG PET imaging |
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