A dynamic,ensemble learning approach to forecast dengue fever epidemic years in Brazil using weather and population susceptibility cycles |
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Authors: | Sarah F McGough Leonardo Clemente J Nathan Kutz Mauricio Santillana |
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Affiliation: | 1.Computational Health Informatics Program, Boston Children''s Hospital, Boston, MA 02115, USA;2.Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA;3.Tecnológico de Monterrey, 64849 Monterrey, Nuevo León, Mexico;4.Department of Applied Mathematics, University of Washington, Seattle, WA 98195, USA;5.Department of Pediatrics, Harvard Medical School, Harvard University, Boston, MA 02115, USA |
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Abstract: | Transmission of dengue fever depends on a complex interplay of human, climate and mosquito dynamics, which often change in time and space. It is well known that its disease dynamics are highly influenced by multiple factors including population susceptibility to infection as well as by microclimates: small-area climatic conditions which create environments favourable for the breeding and survival of mosquitoes. Here, we present a novel machine learning dengue forecasting approach, which, dynamically in time and space, identifies local patterns in weather and population susceptibility to make epidemic predictions at the city level in Brazil, months ahead of the occurrence of disease outbreaks. Weather-based predictions are improved when information on population susceptibility is incorporated, indicating that immunity is an important predictor neglected by most dengue forecast models. Given the generalizability of our methodology to any location or input data, it may prove valuable for public health decision-making aimed at mitigating the effects of seasonal dengue outbreaks in locations globally. |
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Keywords: | dengue forecasting ensemble |
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