Absorption and biliary secretion of intraperitoneally injected 3β-methoxycholest-5-ene-4-14C in the rat |
| |
Authors: | L N Norcia |
| |
Affiliation: | (1) Department of Biochemistry, Temple University School of Medicine, 19140 Philadelphia, Pennsylvania |
| |
Abstract: | Following ip injection of 1 mg amounts of methoxycholestene-4-14C into normal intact rats, the amount of label in the whole liver was measured at different time intervals in different animals.
These studies indicated that most of the injected compound was absorbed by or before 12 hr. In bile duct-cannulated rats the
secretion of label from ip injected methoxycholestene-4-14C or cholesterol-4-14C into bile was usually less during the first 24 hr than during the second 24 hr after injection. Studies on the nature of
the labeled compounds in the bile following ip injection of methoxycholestene-4-14C indicate that most of the label is present in metabolites, 47% of the label in cholic acid and 31% in chenodeoxycholic acid. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|