Bone regeneration using an injectable calcium phosphate/autologous iliac crest bone composites for segmental ulnar defects in rabbits |
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Authors: | Yao Weitao Kong Kangmei Wang Xinjia Qi Weili |
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Affiliation: | (1) Depertment of Orthopedics, He Nan Tumor Hospital, Dongming Road, Zhengzhou, He Nan Province, 450000, China;(2) Dongxiabei Road, Shantou, Gunagdong Province, 515041, China |
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Abstract: | Background Treatment of segmental bone loss remains a challenge in skeletal repair. A major therapeutic goal is the development of implantable
materials that will promote bone regeneration. Objective We evaluate bone regeneration in grafts containing different concentrations autologous iliac crest bone (ACB) particles,
carried in a new injectable calcium phosphate cement (CPC), in ulnar bone defects in rabbits. Methods Large upper-mid-diaphyseal defects (10 mm) were created in the left ulnae of 60 skeletally mature New Zealand white rabbits.
ACB concentrations of 0, 25, 50, 75, and 100% (by volume) in CPC were used to fill operated sites. Defect bridging was monitored
by serial radiography at 4, 8, and 12 weeks post-operation. Samples were then examined histologically and by manual palpation
to determine the extent of new bone formation. Results At 4 weeks, we observed more elaborate structures and extensive absorption in ulnae treated with mixtures containing low
concentrations of ACB (such as 0% and 25% volume of ACB/CPC), compared with those treated with mixtures containing high concentrations
of ACB (such as 75% and 100% volume of ACB/CPC). At 8 weeks, histomorphometry revealed increased trabecular area and volume
in the group treated with high ACB concentrations compared with those treated with low ACB concentrations. At 12 weeks, complete
cortical bridging and regeneration of marrow space were detected in groups treated with high concentrations of ACB, and the
amount of new bone regeneration was greater in these groups than in those treated with low ACB concentrations. Conclusions Treatment of rabbit ulnar defects with injectable CPC carrying an optimized concentration of ACB particles can lead to cortical
bridging and bone marrow regeneration within 12 weeks. |
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