Aberrant methylation of the BRCA1 CpG island promoter is associated with decreased BRCA1 mRNA in sporadic breast cancer cells |
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Authors: | JC Rice KS Massey-Brown BW Futscher |
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Affiliation: | Central Research Laboratories, Kyorin Pharmaceutical Co., Ltd., Tochigi, Japan. |
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Abstract: | A series of N-substituted 4-amino-2,2-diphenylbutyramide derivatives was prepared as part of a search for subtype-selective antimuscarinic agents. The representative compound KRP-197, bearing a 2-methylimidazole ring as a surrogate of aliphatic amine, was found to be a highly potent and both M1- and M3-selective antimuscarinic agent. |
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