Noradrenergic receptor sensitivity in obsessive-compulsive disorders: I. Growth hormone response to clonidine stimulation |
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Authors: | F Brambilla G Perna L Bellodi C Arancio A Bertani G Perini C Carraro F Gava |
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Affiliation: | Departamento de Farmacologia y Toxicologia, Nuevo Leon, Mexico. |
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Abstract: | Dimeric anthracenones obtained from the genus Karwinskia (Rhamnaceae) are characteristic compounds isolated from the plants of this species. Previous toxicity studies demonstrated Diast T-514 to be toxic to animals in experimental settings. Diast T-514 extracted and characterized from Karwinskia parvifolia, was studied in CD1 mice. The LD50 for this compound was determined. Animals were tested with Diast T-514 following enteral and parenteral administration. An LD50 dose by both oral and intraperitoneal administration showed selective damage to target organs. |
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