Gold nanorods mediated controlled release of doxorubicin: nano-needles for efficient drug delivery |
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| Authors: | Sunil Pandey Ritu Shah Ashmi Mewada Mukeshchand Thakur Goldie Oza Madhuri Sharon |
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| Affiliation: | 1. N. S. N. Research Centre for Nanotechnology and Bionanotechnology, Jambhul Phata, Ambernath (W), 421 505, Maharashtra, India
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| Abstract: | Use of cysteamine hydrochloride (Cys-HCl) protected gold nanorods (GNRs) as efficient carrier of widely used anti-cancer drug doxorubicin using folic acid as navigational molecule is presented in this work. GNRs were found to have excellent drug loading capacity of >97 %. A detailed comprehension of in vitro drug release profile under ideal physiological condition was found to obey 1st order kinetics at pH 6.8, 5.3 and 7.2, an ideal milieu for drug delivery to solid tumours. |
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