| 丙硫菌唑的合成研究 |
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| 引用本文： | 马艺超,张蒙萌,申国富,汤保贺,王宽,程绎南,李洪连. 丙硫菌唑的合成研究[J]. 现代农药, 2017, 0(4): 15-17. DOI: 10.3969/j.issn.1671-5284.2017.04.004 |
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| 作者姓名： | 马艺超 张蒙萌 申国富 汤保贺 王宽 程绎南 李洪连 |
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| 作者单位： | 河南农业大学 植保学院,郑州,450002 |
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| 基金项目： | 河南省科技攻关计划项目(172102110042)，公益性行业(农业)科研专项(201503112)，河南省高等学校重点项目(16A210006) |
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| 摘 要： | 以邻氯苄基氯、2-氯-1-(1-氯环丙基)乙酮和水合肼等为主要原料,通过格氏反应、肼的取代、环化和氧化等4步反应合成了丙硫菌唑。目标产物及主要中间体经NMR确认,合成总收率达53%,产品质量分数为95%。该工艺具有反应条件相对温和,反应溶剂易于回收和产品质量好等特点,较适合工业化开发。
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| 关 键 词： | 丙硫菌唑 合成 格氏反应 取代肼 |
Study on the Synthesis of Prothioconazole |
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| MA Yi-chao,ZHANG Meng-meng,SHEN Guo-fu,TANG Bao-he,WANG Kuan,CHENG Yi-nan,LI Hong-lian. Study on the Synthesis of Prothioconazole[J]. Modern Agrochemicals, 2017, 0(4): 15-17. DOI: 10.3969/j.issn.1671-5284.2017.04.004 |
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| Authors: | MA Yi-chao ZHANG Meng-meng SHEN Guo-fu TANG Bao-he WANG Kuan CHENG Yi-nan LI Hong-lian |
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| Abstract: | Prothioconazole was prepared successfully with 2-chlorobenzyl chloride, 2-chloro-1-(1-chlorocyclopropyl) ethanone and hydrazine hydrate, via Grignard reaction, hydrazine substitution, cyclization and oxidation. The total yield of the four synthetic steps reached 53%, and the product purity reached 95%. The procedure showed several advantages such as abundant raw materials, mild reaction conditions, easily recycled reaction solvents, easily purified intermediates and high product quality. It was suitable for industrial development. |
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| Keywords: | prothioconazole synthesis Grignard reaction substituted hydrazine |
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