| 氟吡菌胺的合成工艺研究 |
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| 引用本文： | 高玉清,石强强,潘炳庆,耿来红,徐世栋,张生芳. 氟吡菌胺的合成工艺研究[J]. 现代农药, 2017, 0(1): 26-29. DOI: 10.3969/j.issn.1671-5284.2017.01.006 |
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| 作者姓名： | 高玉清 石强强 潘炳庆 耿来红 徐世栋 张生芳 |
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| 作者单位： | 甘肃省化工研究院,兰州,730020 |
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| 基金项目： | 甘肃省科技支撑计划项目(1304NKCA163) |
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| 摘 要： | 以2,3-二氯-5-三氟甲基吡啶等为起始原料,与硝基甲烷经亲核取代生成3-氯-2-硝基甲基-5-三氟甲基吡啶,再通过氯化亚锡还原得到2-氨基甲基-3-氯-5-三氟甲基吡啶,最后与2,6-二氯苯甲酰氯缩合得到氟吡菌胺。对其合成工艺(反应温度、时间、原料物质的量之比等)进行了讨论,产品及中间体结构经~1H NMR表征确认。在优化条件下,反应总收率为59.5%。该工艺操作简单,条件温和,收率较高。
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| 关 键 词： | 新型杀菌剂 氟吡菌胺 2,3-二氯-5-三氟甲基吡啶 合成 |
Synthesis of Fluopicolide |
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| GAO Yu-qing,SHI Qiang-qiang,PAN Bing-qing,GENG Lai-hong,XU Shi-dong,ZHANG Sheng-fang. Synthesis of Fluopicolide[J]. Modern Agrochemicals, 2017, 0(1): 26-29. DOI: 10.3969/j.issn.1671-5284.2017.01.006 |
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| Authors: | GAO Yu-qing SHI Qiang-qiang PAN Bing-qing GENG Lai-hong XU Shi-dong ZHANG Sheng-fang |
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| Abstract: | The target product fluopicolide was synthesized from 2,3-dichloro-5-(trifluoromethyl)pyridine via nucleophilic substitution reaction, reduction reaction, condensation reaction. The influences of the synthetic technological route were investigated, and the structures of key intermediates and fluopicolide were confirmed by1H NMR. Under optimized conditions, the total yield was 59.5%. This process was simple, the condition was mild. |
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| Keywords: | novel fungicide fluopicolide 2,3-dichloro-5-(trifluoromethyl)pyridine synthesis |
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