Pharmacokinetics of a Transdermal Nicotine Patch Compared to Nicotine Gum |
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| Authors: | James D Lane Eric C Westman Gail V Ripka Jhili Wu Chin-Chih Chiang Jed E Rose |
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| Affiliation: |
a Department of Psychiatry, Duke University Medical Center, Durham, NC
b Nicotine Research Lab, Veterans Affairs Medical Center, Durham, NC
c TBS Laboratories, Inc., Piscataway, NJ |
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| Abstract: | A new transdermal nicotine delivery system (TBS-NCT)was investigated in laboratory and clinical studies with healthy cigarette smokers. Plasma nicotine concentration time profiles were characterized during and after 24-hr application of three doses of TBS-NCT and during and after a 6-hr regimen of nicotine polacrilex gum. Pharmacokinetic analysis revealed dose-related plasma concentrations for transdermal treatments, bracketing the concentrations obtained from nicotine gum. The TBS-NCT system was also well tolerated during a subsequent 4-week open trial and demonstrated a 40% success rate for smoking cessation during the course of the trial. Overall, the TBS-NCT system appears suitable for once-daily application as an aid in smoking cessation treatments. |
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