Synthesis and comparative evaluation of two antiviral agents: beta-L-Fd4C and beta-D-Fd4C |
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| Authors: | SH Chen S Lin I King T Spinka GE Dutschman EA Gullen YC Cheng TW Doyle |
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| Affiliation: | Vion Pharmaceuticals, Inc., Four Science Park, New Haven, CT 06511, USA. |
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| Abstract: | The synthesis of beta-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of beta-D-Fd4C was compared with that of beta-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, beta-L-Fd4C was found to be the most potent antiviral agent. |
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