植物乳杆菌发酵豆乳对多囊卵巢综合征大鼠的影响

为探究植物乳杆菌发酵豆乳缓解大鼠多囊卵巢综合征症状(polycystic ovary syndrome, PCOS)的能力,采用来曲唑灌胃的方式构建PCOS大鼠模型,并以此模型评价了3株植物乳杆菌发酵豆乳对PCOS大鼠体重、卵巢病理学、性激素水平、糖脂代谢等的影响。结果表明,来曲唑给药后大鼠体重以及卵巢重量均显著增加,卵巢呈多囊样改变,性激素水平以及生化指标异常。3株植物乳杆菌发酵豆乳干预后均不同程度减轻了来曲唑引起的大鼠卵巢病变,降低PCOS大鼠血清睾酮、总胆固醇、甘油三酯及低密度脂蛋白胆固醇水平。其中,植物乳杆菌CCFM1019发酵豆乳可以显著增加血清中雌二醇水平,降低谷草转氨酶(aspartate aminotransferase, AST)含量,而植物乳杆菌LP4发酵豆乳可以显著降低血清中促黄体生成素含量以及谷丙转氨酶、AST含量。这些不同植物乳杆菌发酵的豆乳能在不同程度上缓解大鼠PCOS症状。

Effects of soymilk fermented by Lactobacillus plantarum on rats with polycystic ovary syndrome

In order to explore the capability of Lactobacillus plantarum fermented soymilk in alleviating the symptoms of polycystic ovary syndrome(PCOS)in mice,letrozole was used to construct PCOS rat model.The effects of soymilk fermented by three strains of L.plantarum on body weight,ovarian pathology,sex hormone levels,glucose and lipid metabolism of PCOS rats were evaluated separately.The results indicated that the body weight and ovarian weight of rats increased significantly after letrozole administration.The ovaries showed polycystic changes.And the levels of sex hormones and biochemical indicators were abnormal.The intervention of L.plantarum fermented soymilk alleviated the ovarian lesions in rats caused by letrozole and reduced the serum testosterone,triglyceride,total cholesterol and low density lipoprotein levels in PCOS rats.In addition,the L.plantarum CCFM1019 fermented soymilk could significantly increase the serum estradiol level and reduce the content of aspartate aminotransferase(AST),while soymilk fermented by L.plantarum LP4 significantly reduced the content of luteotropic hormone,alanine aminotransferase and AST in serum.The soymilk fermented by different L.plantarum strains can relieve the symptoms of PCOS in rats to varying degrees.