Effects of ethylp-chlorophenoxyisobutyrate on biliary secretion of bile acids,cholesterol and phosphatidyl choline

The effect of chronic administration of ethylp-chlorophenoxyisobutyrate (CPIB) on the secretion of bile lipids was studied in four dogs with surgically implanted Thomas cannulae for periods of 2–7 months. The concentration of cholesterol, triglycerides andp-chlorophenoxyisobutyric acid in serum and of bile acids, cholesterol and phospholipids (phosphatidyl cholines) in bile were measured. Chronic administration of CPIB resulted in a marked increase in the concentration of cholesterol, bile acids and phosphatidyl cholines in the bile of all dogs, and a decrease in serum cholesterol and triglyceride concentration in serum in three of the four dogs. Serum concentrations ofp-chlorophenoxyisobutyric acid were monitored to insure the presence of the drug in the dogs; however, no correlation between serum levels ofp-chlorophenoxyisobutyric acid and the concentration of biliary lipids was noted. The bile acids andp-chlorophenoxyisobutyric acid were determined by gas chromatographic procedures and the structures were confirmed by gas chromatography-mass spectrometry. One of eight papers presented at the symposium “Recent Advances in Drugs Affecting Lipid Metabolism,” AOCS Meeting, Houston, May 1971.