Evidence for the combined participation of a C10 and a C15 precursor in the biosynthesis of moenocinol, the lipid part of the moenomycin antibiotics |
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Authors: | Neundorf Ines Köhler Christian Hennig Lothar Findeisen Matthias Arigoni Duilio Welzel Peter |
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Affiliation: | Fakult?t für Chemie und Mineralogie, Universit?t Leipzig, Johannisallee 29, 04103 Leipzig, Germany. |
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Abstract: | Upon feeding of [2-(13)C,4-(2)H]-1-deoxy-D-xylulose to Streptomyces ghanaensis, the deuterium label was retained exclusively at positions C-7 and C-17 in the moenocinol part of the moenomycin antibiotics. This result vindicates the hypothesis that the C(25) structure of moenocinol is assembled from a C(10) and a C(15) precursor, each of which requires for its formation the involvement of a dimethylallyl diphosphate starter unit. |
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Keywords: | biosynthesis isotopic labeling NMR spectroscopy terpenoids |
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