Room Temperature Synthesis Mediated Porphyrinic NanoMOF Enables Benchmark Electrochemical Biosensing |
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| Authors: | Zhenyu Zhou Jun Wang Shujin Hou Soumya Mukherjee Roland A. Fischer |
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| Affiliation: | 1. School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031 P. R. China;2. Physics of Energy Conversion and Storage, Physic-Department, Technische Universität München, James-Franck-Str. 1, 85748 Garching, Germany;3. Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, V94T9PX Ireland;4. Chair of Inorganic and Metal-Organic Chemistry, Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748 Garching b. München, Germany |
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| Abstract: | Leveraging size effects, nanoparticles of metal-organic frameworks, nanoMOFs, have recently gained traction, amplifying their scopes in electrochemical sensing. However, their synthesis, especially under eco-friendly ambient conditions remains an unmet challenge. Herein, an ambient and fast secondary building unit (SBU)-assisted synthesis (SAS) route to afford a prototypal porphyrinic MOF, Fe-MOF-525 is introduced. Albeit the benign room temperature conditions, Fe-MOF-525(SAS) nanocrystallites obtained are of ≈30 nm size, relatively smaller than the ones conventional solvothermal methods elicit. Integrating Fe-MOF-525(SAS) as a thin film on a conductive indium tin oxide (ITO) surface affords Fe-MOF-525(SAS)/ITO, an electrochemical biosensor. Synergistic confluence of modular MOF composition, analyte-specific redox metalloporphyrin sites, and crystal downsizing contribute to its benchmark voltammetric uric acid (UA) sensing. Showcasing a wide linear range of UA detection with high sensitivity and low detection limit, this SAS strategy coalesces ambient condition synthesis and nanoparticle size control, paving a green way to advanced sensors. |
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| Keywords: | biosensors nanoparticles porphyrinic metal-organic frameworks (MOFs) room temperature synthesis uric acid detection |
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