Identification of the aspartic acid residue located at or near substrate-binding site of rye seed chitinase-c |
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Authors: | T Yamagami G Funatsu |
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Affiliation: | Department of Radiology, Shiga University of Medical Sciences, Otsu, Japan. |
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Abstract: | Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials. |
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