| 气相色谱法测定赖氨肌醇维B12口服溶液中肌醇的含量 |
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| 引用本文： | 李锐,陈梅荣,王晖,赖娟华.气相色谱法测定赖氨肌醇维B12口服溶液中肌醇的含量[J].江西化工,2011(2):77-79. |
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| 作者姓名： | 李锐 陈梅荣 王晖 赖娟华 |
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| 作者单位： | 江西省药物研究所,江西南昌,330029 |
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| 摘 要： | 目的：建立气相色谱法测定赖氨肌醇维B12口服溶液中肌醇的含量。方法：将肌醇进行硅烷化处理，正己烷提取后，以气相色谱法测定其含量。色谱柱为Elite-5ms30m x0.25mm x0.25um毛细管柱；YID检测器；载气为氮气；柱温为210℃；检测器温度为250℃；分流比为50:1。结果：肌醇浓度在0.050-10.0...
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| 关 键 词： | 气相色谱法 赖氨肌醇维B12口服溶液 肌醇 含量测定 |
Determination of Inosite in Lysine,Inosite and Vitamin B_(12) Oral Solution by GC |
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| Li Rui,Chen Mei-rong,Wang Hui,Lai Juan-hua.Determination of Inosite in Lysine,Inosite and Vitamin B_(12) Oral Solution by GC[J].Jiangxi Chemical Industry,2011(2):77-79. |
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| Authors: | Li Rui Chen Mei-rong Wang Hui Lai Juan-hua |
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| Affiliation: | Li Rui Chen Mei-rong Wang Hui Lai Juan-hua(Jiangxi Province Institute of Materia Medica,Nachang 330029) |
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| Abstract: | Objective to establish a method for determination of Inosite in Lysine,Inosite and Vitamin B12 Oral Solution.METHOD After silanization,the inosite was extracted with n-hexane and determined by GC.The GC system consisted of a Elite-5ms capillary column（30m×0.25mm×0.25um）,nitrogen as the carrier gas,column temperature at 210℃,FID as the detector at 250℃,and with a split ratio of 50：1.RESULTS There was a good linear within the range of 0.050~10.020mg/ml for inosite with г=0.9998（n=7）.The average recovery was 98.03% with RSD=1.98%（n=6）.CONCLUSION The method is accurate,reproducible and could be used for the quality control ofLysine,Inosite and Vitamin B12 Oral Solution. |
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| Keywords: | GC Lysine Inosite and Vitamin B12 Oral Solution inosite determination |
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