| 青霉素G亚砜的合成 |
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| 引用本文： | 杨莉,刘智凌. 青霉素G亚砜的合成[J]. 精细化工中间体, 2007, 37(6): 36-38 |
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| 作者姓名： | 杨莉 刘智凌 |
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| 作者单位： | 南京林业大学化学工程学院,江苏,南京,210037;湖南化工研究院,湖南,长沙,410007 |
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| 摘 要： | 以青霉素G钾盐为原料,采用15%左右低浓度过氧乙酸为氧化剂合成青霉素G亚砜,反应时间2～2.5h,n(过氧乙酸):n(青霉素G钾盐)=(1.1～1.2):1.0,反应温度和结晶温度在0～5℃,总收率可达96%以上。所得青霉素G亚砜可直接从溶液中结晶析出,解决了产物与反应体系的分离。产品纯度较高。
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| 关 键 词： | 青霉素G钾 低浓度过氧乙酸 青霉素G亚砜 |
| 文章编号： | 1009-9212（2007）06-0026-03 |
| 收稿时间： | 2007-11-20 |
| 修稿时间： | 2007-11-20 |
Synthesis of Penicillin G Sulfoxide |
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| YANG Li,LIU Zhi-lin. Synthesis of Penicillin G Sulfoxide[J]. Fine Chemical Intermediates, 2007, 37(6): 36-38 |
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| Authors: | YANG Li LIU Zhi-lin |
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| Abstract: | Penicillin G potassium salt is oxidized with 15% low concentration of peroxyacetic acid to synthesize penicillin G sulfoxide.The optimal conditions were as follows:reaction time 2.0～2.5 h,mole ratio of peroxyacetic acid and penicillin G K =(1.1～1.2):1.0,reaction and crystal temperature 0～5℃.The total yield of product was over 96%.The product could be crystallized directly from the solution and thus the separating problem was resolved.The purity of the product was high. |
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| Keywords: | penicillin G potassium salt low concentration of peroxyacetic acid penicillin G sulfoxide |
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