Efficacy of lytic peptide-bound magnetite nanoparticles in destroying breast cancer cells |
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Authors: | Kumar Challa S Leuschner Carola Doomes E E Henry Larry Juban Martha Hormes Josef |
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Affiliation: | Center for Advanced Microstructures and Devices, Louisiana State University, 6980 Jefferson Hwy, Baton Rouge, Louisiana 70806, USA. |
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Abstract: | A 23-amino-acid synthetic lytic peptide (Hecate) was covalently linked to magnetite nanoparticles and the lytic peptide-bound nanoparticles were characterized by X-ray absorption near-edge structure spectroscopy, transmission electron microscopy, and electron diffraction. Investigation of magnetic properties with a superconducting quantum interference device (SQUID) magnetometer has shown a reduction in the saturation magnetization (Ms) of magnetite nanoparticles after binding with lytic peptide. An in vitro cell culture assay with breast cancer cell lines MDA-MB-435S revealed that the lytic peptide-bound magnetite nanoparticles were therapeutically active. |
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