| 3H-RNA示踪法研究大鼠口服核糖核酸后的组织分布 |
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| 引用本文： | 张洪卫,李怀芬,李恕,刘庆莹,牛惠生. 3H-RNA示踪法研究大鼠口服核糖核酸后的组织分布[J]. 同位素, 2006, 19(3): 166-169. DOI: 10.7538/tws.2006.19.03.0166 |
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| 作者姓名： | 张洪卫 李怀芬 李恕 刘庆莹 牛惠生 |
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| 作者单位： | 1. 中国医学科学院,放射医学研究所,天津,300192
2. 大连珍奥集团股份有限公司,辽宁,大连,116620 |
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| 摘 要： | 利用3H-RNA示踪法研究了大鼠口服核糖核酸(RNA)制剂(80mg/kg)后0.5、1.0、4.0和10.0 h RNA代谢产物在脑、甲状腺、胸腺、心、肺、肝，脾、胃、小肠、结肠、肾、睾丸、子宫、肌肉和皮肤的分布，旨在对核酸类生物制品的深度开发提供依据。结果显示，大鼠口服RNA后，其代谢产物在各器官中均有分布，除在胃和肠中含量很高外，在神经、内分泌和免疫相关组织中含量也较高。在给药后10 h时RNA代谢产物在组织中仍有一定含量，这表明RNA已被组织利用。
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| 关 键 词： | 核糖核酸3H-放射性示踪组织分布 |
| 文章编号： | 1000-7512（2006）03-0166-03 |
| 收稿时间： | 2006-01-06 |
| 修稿时间： | 2006-05-08 |
The Histological Distribution of Ridonucleic Acid Taken Orally by Rat With 3H-RNA Tracing Technique |
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| ZHANG Hong-Wei,LI Huai-fen,LI She,LIU Qing-ying,NIU Hui-Sheng. The Histological Distribution of Ridonucleic Acid Taken Orally by Rat With 3H-RNA Tracing Technique[J]. Isotopes, 2006, 19(3): 166-169. DOI: 10.7538/tws.2006.19.03.0166 |
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| Authors: | ZHANG Hong-Wei LI Huai-fen LI She LIU Qing-ying NIU Hui-Sheng |
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| Affiliation: | Institute Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China ; 2. Dalian Zhen-ao Group Company, Dalian 116620, China |
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| Abstract: | The rat histological distribution of ribonucleic acid(RNA) metabolite are detected by ~3H-RNA radioactive tracing technique.The results indicate that the RNA metabolites are distributed in every organ of the rat after taking orally.The RNA metabolite contents are higher in nervous,endocrine and immune systems in addition to stomach and intestine.The certain amount of RNA metabolite is still maintained in tissues at 10.0 h after taking RNA orally.It indicates that RNA has been used by the tissues. |
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| Keywords: | ~3H ribonucleic acid histological distribution |
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