杜仲雄花正丁醇提取物的镇静催眠作用研究

研究不同剂量杜仲雄花正丁醇提取物的镇静催眠作用,确定杜仲雄花镇静催眠活性部位并分析其有效作用剂量.观察不同剂量正丁醇提取物对小鼠自主活动的影响以及直接镇静催眠作用、与戊巴比妥钠的协同作用和抗惊厥作用.杜仲雄花正丁醇提取物能显著增加小鼠睡眠率,减少小鼠的自主活动次数;显著增加阈下剂量戊巴比妥钠小鼠睡眠率,延长阈上剂量戊巴比妥钠睡眠时间,缩短入睡潜伏期;显著减少惊厥小鼠数,延长惊厥潜伏期.杜仲雄花正丁醇提取物具有良好的镇静催眠作用.

Study on the sedative and hypnotic effects of n-butyl alcohol extracts of eucommia male flowers

Study the sedative and hypnotic effects of n-butyl alcohol extracts of Eucommia male flowers with different dose. Confirm the effective part of Eucommia male flowers and investigate the effective dosage of it. Extract active components in Eucommia male flowers with the n-butyl alcohol. We investigated the effects on spontaneous activity of mice, the synergy operation with pentobarbital sodium, and anticonvulsant effects of n-butyl alcohol extracts of Eucommia male flowers with different dose. N-butyl alcohol extracts of Eucommia male flowers could induce mice to sleep or significantly inhibit the spontaneous activity, enhance the amount of sleeping mice with pentobarbital sodium of subthreshold dose, prolong the sleeping time and shorten the sleep latency of pentobarbital sodium of superthreshold dose; effectively reduce the eclamptic rate of mice and significantly prolonged the convulsions latency. N-butyl alcohol extracts of Eucommia male flowers possess obviously sedative and hypnotic effects in mice which are the effective part of Eueommia male flowers.