| Change in Shape and Crystal Structure of HAP Nanoparticles during Absorption into Cell |
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| 引用本文： | 扈盛,李世普. Change in Shape and Crystal Structure of HAP Nanoparticles during Absorption into Cell[J]. 武汉理工大学学报(材料科学英文版), 2007, 22(3): 443-445. DOI: 10.1007/s11595-006-3443-1 |
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| 作者姓名： | 扈盛 李世普 |
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| 作者单位： | Biomedical Materials and Engineering Center Wuhan University of Technology，Biomedical Materials and Engineering Center，Wuhan University of Technology，Wuhan 430070，China College of Health Science，Wuhan Institute of Physical Education，Wuhan 430079，China，Wuhan 430070，China |
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| 摘 要： | The change of hydroxyapatite （HAP） nanoparticles in shape and crystal structure after endocytosis into cancer cells was studied. BEL7402 cells were incubated with HAP nanoparticles for 2 hour, 8 hours, 20 hours, respectively. Then, the cells were collected and viewed under a transmission electronic microscope （TEM）. Electronic diffraction （ED） attached to TEM was used to detect the properties of the particles. The results show that HAP particles in the cytoplasm can be degraded in cytoplasm. The degradation process is prolonged by more than 20 hours. Thus, it is concluded that HAP nanoparticles would be degraded after kill cells or delivery gene.
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| 关 键 词： | 羟磷灰石纳米颗粒 癌症细胞 生物材料 生物降解 晶体结构 |
| 收稿时间： | 2006-03-19 |
| 修稿时间： | 2006-03-19 |
Change in shape and crystal structure of HAP nanoparticles during absorption into cell |
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| Hu Sheng,Yan Yuhua,Wang Youfa,Han Yingchao,Li Shipu. Change in shape and crystal structure of HAP nanoparticles during absorption into cell[J]. Journal of Wuhan University of Technology. Materials Science Edition, 2007, 22(3): 443-445. DOI: 10.1007/s11595-006-3443-1 |
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| Authors: | Hu Sheng Yan Yuhua Wang Youfa Han Yingchao Li Shipu |
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| Affiliation: | (1) Biomedical Materials and Engineering Center, Wuhan University of Technology, Wuhan, 430070, China;(2) College of Health Science, Wuhan Institute of Physical Education, Wuhan, 430079, China |
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| Abstract: | The change of hydroxyapatite (HAP) nanoparticles in shape and crystal structure after endocytosis into cancer cells was studied. BEL7402 cells were incubated with HAP nanoparticles for 2 hour,8 hours,20 hours,respectively. Then,the cells were collected and viewed under a transmission electronic microscope (TEM). Electronic diffraction (ED) attached to TEM was used to detect the properties of the particles. The results show that HAP particles in the cytoplasm can be degraded in cytoplasm. The degradation process is prolonged by more than 20 hours. Thus,it is concluded that HAP nanoparticles would be degraded after kill cells or delivery gene. |
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| Keywords: | HAP nanoparticle cancer cell degradation |
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